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how long after a cold sore can you give oral? The complete healing process of a cold sore might take 7-10 days. However, the process may be shortened with the use of antiviral medications. The indication that its safer to have oral sex is when the cold sore is nowhere to be seen.how long after a cold sore can you give oral? The complete healing process of a cold sore might take 7-10 days. However, the process may be shortened with the use of antiviral medications