Women vary in the degree of discomfort that they feel. Most people have mild to moderate cramping. Some women have severe cramping during the procedure. The cramping will lessen shortly after the biopsy is finished.

Will an endometrial biopsy hurt?

Is endometrial biopsy painful? It can be uncomfortable. The placement of the thin plastic catheter inside the uterus can produce cramping. Take four 200-mg tablets of ibuprofen (brand names: Advil, Motrin, Nuprin) with some food about an hour before coming to the office for the procedure.